In building the high throughput screening operation at our institute, the Genera Laboratory automation systems were chosen for their flexibility to integrate a heterogeneous mix of equipment from different manufacturers and vendors. This has allowed us to shop competitively for each item and still have system integration software that is tailored to our needs. The development environment of Genera is well structured to allow resident programmers with Java experience to add new processes, equipment and data management protocols that were not originally envision when we first setup the system. During long screens it has been useful to have Genera e-mail me system messages keeping me abreast of any errors that equipment might have. We are looking forward to our continued use and development of Genera as our system integration software while our screening facility grows and accommodates new equipment.